Environmental and genetic factors may modify or contribute to the phenotypic differences observed in multigenic and monogenic diseases, such as cystic fibrosis (CF). An analysis of modifier genes can be helpful for estimating patient prognosis and directing preventive care. The aim of this study is to determine the association between seven genetic variants of four modifier genes and CF by comparing their corresponding allelic and genotypic frequencies in CF patients (n = 81) and control subjects (n = 104). Genetic variants of MBL2 exon 1 (A, B, C and D), the IL-8 promoter (−251 A/T), the TNFα promoter (TNF1/TNF2), and SERPINA1 (PI*Z and PI*S) were tested in CF patients and control subjects from northeastern Mexico by PCR-RFLP. Results The TNF2 allele (P = 0.012, OR 3.43, 95% CI 1.25–9.38) was significantly associated with CF under the dominant and additive models but was not associated with CF under the recessive model. This association remained statistically significant after adjusting for multiple tests using the Bonferroni correction (P = 0.0482). The other tested variants and genotypes did not show any association with the disease. Conclusion An analysis of seven genetic variants of four modifier genes showed that one variant, the TNF2 allele, appears to be significantly associated with CF in Mexican patients.
Fibrogenic Polymorphisms (TGF-β, PAI-1, AT) in Mexican Patients with Established Liver Fibrosis. Potential Correlation with Pirfenidone Treatment - Juan Armendáriz-Borunda, Ana Rosa Rincón, José Francisco Muñoz-Valle, Miriam Bueno-Topete, Edith Oregón
Identification of Key Genes and Underlying Mechanisms in Cystic Fibrosis and its Associated Complications Based on Bioinformatics Analysis of Next Generation Sequencing Data Analysis
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PDF) Characterization of Single-Nucleotide Polymorphisms in the Tumor Necrosis Factor α Promoter Region and in Lymphotoxin α in Squamous Intraepithelial Lesions, Precursors of Cervical Cancer
Sc.D. Hugo Gallardo Blanco – Kudos: Growing the influence of research
The Tumor Necrosis Factor α (-308 A/G) Polymorphism Is Associated with Cystic Fibrosis in Mexican Patients
Advances in Clinical and Experimental Medicine
The Tumor Necrosis Factor α (-308 A/G) Polymorphism Is Associated with Cystic Fibrosis in Mexican Patients
PDF) Influence of the −308 TNF-α and −174 IL6 polymorphisms on lipid profile in Mexican subjects
Fibrogenic Polymorphisms (TGF-β, PAI-1, AT) in Mexican Patients with Established Liver Fibrosis. Potential Correlation with Pirfenidone Treatment - Juan Armendáriz-Borunda, Ana Rosa Rincón, José Francisco Muñoz-Valle, Miriam Bueno-Topete, Edith Oregón
Epigenetics of Idiopathic Pulmonary Fibrosis
Tumor necrosis factor-α (TNF-α) -308G >a promoter polymorphism (rs1800629) promotes Asians in susceptibility to Plasmodium falciparum severe malaria: A meta-analysis
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